Osteoadherin (OSAD) was first isolated from the mineralised matrix of bone (Wendel et al. 1998), its mRNA being specifically detected in bovine and rat mature osteoblasts located superficially on trabecular bone (Sommarin et al. 1998; Shen et al. 1999).

Anti-OMD antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonym: SLRR2C, osteoadherin; find Sigma-Aldrich-HPA069948 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.

Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucine-rich proteoglycans (SLRP). Leucine-rich repeat (LRR) motifs consist of approximately 20 - 30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta-sheet and one alpha-helix. 2017-02-28 Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is encoded by the OMD gene. References Further reading. This page was last edited on 12 October 2020, at 04:35 (UTC). Text is available under the Creative Commons Attribution Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin. The human protein, encoded by the gene OMD, is 421 amino acid residues long and has a mass of 49,492 daltons.

Osteoadherin

Abstract Osteoadherin is a recently described bone … A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine hydrochloride–containing EDTA. It was purified to homogeneity using a combination of ion-exchange chromatography, hydroxyapatite chromatography, and gel filtration. The Mr of the proteoglycan was 85,000 as determined by OSTEOADHERIN. From THE INSTITUTE OF ODONTOLOGY, CENTER FOR ORAL BIOLOGY Karolinska Institutet, Stockholm, Sweden REGULATION AND FUNCTION OF MINERALIZED TISSUE EXTRA-CELLULAR MATRIX PROTEINS: STUDIES OF ADAMTS-1 AND OSTEOADHERIN Anders Rehn Stockholm 2008 . 2008 Gårdsvägen 4, 169 70 Solna Osteoadherin also interacts with calcium phosphate mineral , suggesting that osteoadherin contributes to biomineralization and the control of mineral crystal nucleation, growth, and maturation. Although few previous reports show regulation of Omd expression by growth factors and signaling molecules, Rehn et al ( 30 ) reported that transforming growth factor-β (TGF-β) down-regulates Omd 1999-12-30 The Human Osteoadherin IQELISA™ kit is an ultrasensitive ELISA utilizing qPCR detection for 10X more sensitivity with 10X less sample. See more Osteoadherin/OSAD/OMD products: Catalog# EK2017: Storage & Handling: Store at 4˚C for 6 months, at -20˚C for 12 months.

1998-05-01 · In addition, pure osteoadherin was shown not to react with antisera against other acidic glycoproteins from bone matrix such as osteonectin, osteopontin, bone sialoprotein, decorin, or biglycan. Osteoadherin seems to be restricted to bone as assayed by an inhibition ELISA. Other proteins exclusively restricted to bone include osteocalcin and BSP.

27047 Ensembl ENSG00000127083 ENSMUSG00000048368 UniProt Q99983 O35103 RefSeq (mRNA) NM_005014 NM_012050 NM_001360708 RefSeq (protein) NP_005005 NP_036180 NP_001347637 Location (UCSC) Chr 9: 92.41 – 92.42 Mb Chr 13: 49.58 – 49.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin. The human protein, encoded by the gene OMD, is 421 amino acid residues long and has a mass of 49,492 daltons. It is a member of the Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily. This protein is reported to have a secreted cellular Anti-OMD antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody; Synonym: SLRR2C, osteoadherin; find Sigma-Aldrich-HPA069948 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.

Transforming growth factor beta 1 (TGF g 1) is generally considered to be a potent inducer of dentin formation. In order to further assess this role, we studied the influence of this factor in human dental pulp cells on the expression of osteoadherin (OSAD), a newly described proteoglycan found in bone and dentin and suspected to play a role in mineralization events.

Among its related pathways are Diseases of glycosylation and HIV Life Cycle . An important paralog of this gene is KERA. Human Osteoadherin/Osteomodulin ELISA Kit from Invitrogen (96 Tests). Quantitate human OMD in supernatant, serum and plasma. Sensitivity: 1.4 ng/mL Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone. Based on results obtained from in vitro experiments, the protein was shown to bind osteoblasts via the integrin receptor alpha(v)beta(3). Due to OSAD's capacity to bind hydroxyapatite crystals, a role for the protein in the mineralization process has also been suggested.

Osteoadherin (osteomodulin) is a 49,116-Da protein containing 11 leucine-rich repeats (LRRs), 3-4 tyrosine sulfate residues at the N-terminus, and six potential glycosylation sites for N-linked KS Osteoadherin/OSAD/OMD Polyclonal antibody specifically detects Osteoadherin/OSAD/OMD in Human, Mouse, Rat, Porcine, Bovine, Canine, Equine, Guinea Pig, Rabbit, Zebrafish samples. It is validated for Western Blot.
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Leucine-rich repeat (LRR) motifs consist of approximately 20 - 30 amino acids (aa) with conserved leucine spacing, folded into a structure with one beta-sheet and one alpha-helix. 27047 Ensembl ENSG00000127083 ENSMUSG00000048368 UniProt Q99983 O35103 RefSeq (mRNA) NM_005014 NM_012050 NM_001360708 RefSeq (protein) NP_005005 NP_036180 NP_001347637 Location (UCSC) Chr 9: 92.41 – 92.42 Mb Chr 13: 49.58 – 49.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Osteomodulin (also called osteoadherin or osteoadherin proteoglycan) is a protein that in humans is Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin.
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Osteoadherin, fibromodulin, and chondroadherin, which bind C1q and activate complement, were found to cause significantly higher C9 deposition in C4BP-depleted serum compared with Igs, indicating that the level of complement activation initiated by SLRPs is regulated by simultaneous binding to C4BP.

J Biol Chem 273:16723–16729 PubMed CrossRef Google Scholar Transforming growth factor beta 1 (TGF g 1) is generally considered to be a potent inducer of dentin formation. In order to further assess this role, we studied the influence of this factor in human dental pulp cells on the expression of osteoadherin (OSAD), a newly described proteoglycan found in bone and dentin and suspected to play a role in mineralization events. Osteoadherin (OSAD), also known as Osteomodulin, is an extracellular matrix keratan sulfate proteoglycan that belongs to the class II subfamily of small leucinerich proteoglycans (SLRP).

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Listed are ELISA Kits for the detection of Osteoadherin, an alias name of osteomodulin. The human protein, encoded by the gene OMD, is 421 amino acid residues long and has a mass of 49,492 daltons. It is a member of the Small leucine-rich proteoglycan (SLRP) family, SLRP class II subfamily. This protein is reported to have a secreted cellular

800-343-7475; Contact Us; Cart Osteoadherin (B-10) is a mouse monoclonal antibody raised against amino acids 221-380 mapping within an internal region of Osteoadherin of human origin. PRODUCT Each vial contains 200 µg IgG 1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. Osteoadherin (B-10) is available conjugated to agarose (sc-271102 AC), Current students New students International Desk Academic matters & support IT services & support Careers Service Osteoadherin staining was strong in the whole odontoblast layer (with a slight to the surrounding predentin/dentin/pulp matrix, possibly through osteoadherin. Osteomodulin (OMD), also called osteoadherin, belongs to the family of leucine- rich repeat proteins (SLRPs) of the extracellular matrix, which have crucial roles 人Osteoadherin ELISA for serum, plasma and cell culture supernatants; find Sigma-Aldrich-RAB1619 MSDS, related peer-reviewed papers, technical May 4, 1998 A small cell-binding proteoglycan for which we propose the name osteoadherin was extracted from bovine bone with guanidine Mar 20, 2003 Osteoadherin (OSAD) is a keratan sulfate‐containing proteoglycan, belonging to the small leucine‐rich proteoglycan (SLRP) family. In bone Aug 6, 2009 Transforming growth factor beta 1 (TGF g 1) is generally considered to be a potent inducer of dentin formation. In order to further assess this Recently, osteoadherin (OSAD) has been described as a new member of this family, that is expressed by mature bovine osteoblasts.

Osteoadherin, fibromodulin, and chondroadherin, which bind C1q and activate complement, were found to cause significantly higher C9 deposition in C4BP-depleted serum compared with Igs, indicating that the level of complement activation initiated by SLRPs is regulated by simultaneous binding to C4BP.

Utility Header Menu Right. 800-343-7475; Contact Us; Cart Osteoadherin (B-10) is a mouse monoclonal antibody raised against amino acids 221-380 mapping within an internal region of Osteoadherin of human origin.

Diseases associated with OMD include Bladder Carcinoma In Situ and Anthracosilicosis . Among its related pathways are Diseases of glycosylation and HIV Life Cycle . An important paralog of this gene is KERA. Human Osteoadherin/Osteomodulin ELISA Kit from Invitrogen (96 Tests). Quantitate human OMD in supernatant, serum and plasma. Sensitivity: 1.4 ng/mL Osteoadherin (OSAD) is a keratan sulfate proteoglycan recently isolated from bovine and rat bone.